Journal of Natural Science Research and Review (JNSRR) · Research article · Open access
Integrative Biochemical Diagnostics: From Prenatal Genomics to Environmental and Behavioral Biomarkers
Ian Pranandi
29 November 2025 · Vol. 1, Issue 5, pp. 123-130
DOI: 10.65150/EP-jnsrr/V1E5/2025-05
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What is this article about?
Biochemical diagnostics are undergoing a profound transformation driven by advances in genomics, bioinformatics, environmental biosensing, and circadian physiology. This short review synthesizes emerging developments across these domains to propose an integrative framework for modern diagnostic practice.
Article at a glance
- Published
- 29 November 2025
- Volume / issue / pages
- Vol. 1, Issue 5, pp. 123-130
- ISSN
- 3051-3766 (online) · 3051-3758 (print)
- Licence
- CC BY 4.0 — free to read and reuse with attribution
- Peer review
- Double-blind, at least two independent reviewers
- Publisher
- EP Journals Group
Abstract
Biochemical diagnostics are undergoing a profound transformation driven by advances in genomics, bioinformatics, environmental biosensing, and circadian physiology. This short review synthesizes emerging developments across these domains to propose an integrative framework for modern diagnostic practice. Non-invasive prenatal testing using cell-free fetal DNA and RNA has expanded early detection of genetic and developmental abnormalities, while bioinformatics-driven identification of salivary and metabolic biomarkers has enabled accessible, low-burden assessment of detoxification pathways and metabolic phenotypes. Environmental exposures such as microplastics and endocrine-disrupting chemicals add a critical external dimension to biochemical variation, interacting with culturally mediated behaviors and dietary patterns to shape population-level metabolic traits. Circadian rhythms introduce a temporal layer of physiological regulation, with artificial intelligence now capable of modeling hormonal and metabolic oscillations to improve diagnostic accuracy and chronotherapy planning. Together, these interconnected domains highlight the need for comprehensive, multidimensional diagnostic strategies that reflect the complexity of human biology. Integrating genetic, environmental, cultural, and temporal determinants offers a more precise and equitable pathway toward personalized medicine and population health monitoring.
Keywords: Biochemical diagnostics, prenatal genomics, salivary biomarkers, environmental biosensing, circadian physiology, bioinformatics, microRNAs, artificial intelligence
Cite this article
Ian Pranandi (2025). Integrative Biochemical Diagnostics: From Prenatal Genomics to Environmental and Behavioral Biomarkers. Journal of Natural Science Research and Review, 1(5), 123-130. https://doi.org/10.65150/EP-jnsrr/V1E5/2025-05
@article{Ian2025,
title = {Integrative Biochemical Diagnostics: From Prenatal Genomics to Environmental and Behavioral Biomarkers},
author = {Ian Pranandi},
journal = {Journal of Natural Science Research and Review},
year = {2025},
volume = {1},
number = {5},
pages = {123-130},
doi = {10.65150/EP-jnsrr/V1E5/2025-05},
url = {https://doi.org/10.65150/EP-jnsrr/V1E5/2025-05}
}Questions about this article
Who wrote this article?
Ian Pranandi.
Where and when was it published?
In Journal of Natural Science Research and Review, Volume 1, Issue 5, pages 123-130, published by EP Journals Group on 29 November 2025.
Is this article free to read?
Yes. It is open access under a Creative Commons Attribution 4.0 (CC BY 4.0) licence, so anyone can read, share and reuse it with attribution.
What is the DOI of this article?
10.65150/EP-jnsrr/V1E5/2025-05 (https://doi.org/10.65150/EP-jnsrr/V1E5/2025-05).
How do I cite this article?
APA: Ian Pranandi (2025). Integrative Biochemical Diagnostics: From Prenatal Genomics to Environmental and Behavioral Biomarkers. Journal of Natural Science Research and Review, 1(5), 123-130. https://doi.org/10.65150/EP-jnsrr/V1E5/2025-05
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